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Mechanism of hydrolysis of a platinum(IV) complex discovered by atomic telemetry
Polish Acad Sci, Inst Nucl Phys, PL-31342 Krakow, Poland.
Polish Acad Sci, Inst Phys Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland.ORCID iD: 0000-0002-5508-0533
PTB, Abberstr 2-12, D-10587 Berlin, Germany.ORCID iD: 0000-0002-0301-2918
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
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2018 (English)In: Journal of Inorganic Biochemistry, ISSN 0162-0134, E-ISSN 1873-3344, Vol. 187, p. 56-61Article in journal (Refereed) Published
Abstract [en]

Herein we report on the hydrolysis mechanism of [Pt{N(p-HC6F4)CH2}(2)(NC5H5)(2)(OH)(2)], a platinum(IV) complex that exhibits anti-cancer properties. Atomic telemetry, an in situ technique based on electron structure sensitive X-ray spectroscopy, revealed that hydrolysis preceded any reduction of the metal center. The obtained results are complemented with F-19 NMR measurements and theoretical calculations and support the observation that this Pt-II complex does not reduce spontaneously to Ptll in HEPES buffer solution at pH 7.4 and after 24 h incubation. These results are of importance for the design of novel Pt-based coordination complexes as well as understanding their behavior under physiological conditions.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2018. Vol. 187, p. 56-61
Keywords [en]
Atomic telemetry, Hydrolysis mechanism, In situ measurement, Anti-cancer Pt complex
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-362089DOI: 10.1016/j.jinorgbio.2018.07.012ISI: 000442715000006PubMedID: 30055396OAI: oai:DiVA.org:uu-362089DiVA, id: diva2:1253079
Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-10-03Bibliographically approved

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Fernandes, Daniel L. A.

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