uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cathepsins: Proteases that are vital for survival but can also be fatal
San Diego State Univ, Bioinformat & Med Informat Res Ctr, 5500 Campanile Dr, San Diego, CA 92182 USA.
Univ Hormozgan, Fac Marine Sci & Technol, Dept Marine Biol, Bandar Abbas, Iran;Univ Hormozgan, Dept Biol, Fac Sci, Bandar Abbas, Iran.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. KTH, Sch Chem Sci & Engn, Dept Chem, Ecol Chem Grp, Stockholm, Sweden.
Univ Guelph, Dept Anim Biosci, Guelph, ON N1G 2W1, Canada.ORCID iD: 0000-0002-0574-1102
2018 (English)In: Biomedicine and Pharmacotherapy, ISSN 0753-3322, E-ISSN 1950-6007, Vol. 105, p. 526-532Article in journal (Refereed) Published
Abstract [en]

The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles, which are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a litany of other functions. But inflammatory state radically affects their normal roles. Released from the lysosomes, they degrade extracellular matrix proteins such as collagen and elastin, mediating parasite infection, autoimmune diseases, tumor metastasis, cardiovascular issues, and neural degeneration, among other health hazards. Over the years, the different types and isoforms of cathepsin, their optimal pH and functions have been studied, yet much information is still elusive. By taming and harnessing cathepsins, by inhibitors and judicious lifestyle, a gamut of malignancies can be resolved. This review discusses these aspects, which can be of clinical relevance.

Place, publisher, year, edition, pages
2018. Vol. 105, p. 526-532
Keywords [en]
Cathepsin, Immune activation, Inflammation, Extracellular matrix, Carcinogenesis, Inhibitors
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-363103DOI: 10.1016/j.biopha.2018.05.148ISI: 000438312600058PubMedID: 29885636OAI: oai:DiVA.org:uu-363103DiVA, id: diva2:1256262
Available from: 2018-10-16 Created: 2018-10-16 Last updated: 2018-10-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

El-Seedi, Hesham

Search in DiVA

By author/editor
El-Seedi, HeshamAkhtar, Nadeem
By organisation
Farmakognosi
In the same journal
Biomedicine and Pharmacotherapy
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 50 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf