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Biomechanical analysis of fluid percussion model of brain injury
Western Univ, Dept Mech & Mat Engn, London, ON N6A 5B9, Canada.
Western Univ, Dept Mech & Mat Engn, London, ON N6A 5B9, Canada.
Western Univ, Dept Mech & Mat Engn, London, ON N6A 5B9, Canada.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurosurgery.
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2018 (English)In: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 77, p. 228-232Article in journal (Refereed) Published
Abstract [en]

Fluid percussion injury (FPI) is a widely used experimental model for studying traumatic brain injury (TBI). However, little is known about how the brain mechanically responds to fluid impacts and how the mechanical pressures/strains of the brain correlate to subsequent brain damage for rodents during FPI. Hence, we developed a numerical approach to simulate FPI experiments on rats and characterize rat brain pressure/strain responses at a high resolution. A previous rat brain model was improved with a new hexahedral elements-based skull model and a new cerebrospinal fluid (CSF) layer. We validated the numerical model against experimentally measured pressures from FPI. Our results indicated that brain tissues under FPI experienced high pressures, which were slightly lower (10-20%) than input saline pressure. Interestingly, FPI was a mixed focus- and diffuse-type injury model with highest strains (12%) being concentrated in the ipsilateral cortex under the fluid-impact site and diffuse strains (5-10%) being spread to the entire brain, which was different from controlled cortical impact in which high strains decreased gradually away from the impact site.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2018. Vol. 77, p. 228-232
Keywords [en]
Fluid percussion injury, Finite element, Brain injury, Intracranial pressure, Strain
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-363930DOI: 10.1016/j.jbiomech.2018.07.004ISI: 000442060100032PubMedID: 30031650OAI: oai:DiVA.org:uu-363930DiVA, id: diva2:1258382
Available from: 2018-10-24 Created: 2018-10-24 Last updated: 2018-10-24Bibliographically approved

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