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Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0002-1332-7067
Moscow MV Lomonosov State Univ, Moscow, Russia..
Moscow MV Lomonosov State Univ, Moscow, Russia.;Univ Haifa, Tauber Bioinformat Res Ctr, Haifa, Israel..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. ..
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2018 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1695, p. 78-83Article in journal (Refereed) Published
Abstract [en]

The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pain model. Effects of the left- and right-side SNL on expression of EOS genes in the ipsi- and contralateral spinal domains were analysed. The SNL-induced changes were complex and different between the genes; between the dorsal and ventral spinal domains; and between the left and right sides of the spinal cord. Prodynorphin (Pdyn) expression was upregulated in the ipsilateral dorsal domains by each the left and right-side SNL, while changes in expression mu-opioid receptor (Oprm I) and proenkephalin (Penk) genes were dependent on the SNL side. Changes in expression of the Pdyn and kappa-opioid receptor (Oprk1) genes were coordinated between the ipsi- and contralateral sides. Withdrawal response thresholds, indicators of mechanical allodynia correlated negatively with Pdyn expression in the right ventral domain after right side SNL. These findings suggest multiple roles of the EOS gene products in spinal sensitization and changes in motor reflexes, which may differ between the left and right sides. (C) 2018 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 1695, p. 78-83
Keywords [en]
Rat model, Neuropathic pain, Gene expression, Opioid system, Lumbar spinal cord, Lateralization
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-364899DOI: 10.1016/j.brainres.2018.05.043ISI: 000440390700009PubMedID: 29852138OAI: oai:DiVA.org:uu-364899DiVA, id: diva2:1262191
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareSwedish Research Council FormasSwedish InstituteAvailable from: 2018-11-09 Created: 2018-11-09 Last updated: 2018-11-09Bibliographically approved

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Kononenko, OlgaWatanabe, HiroyukiBazov, IgorSarkisyan, DaniilIatsyshyna, AnnaYakovleva, TatianaBakalkin, Georgy

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