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The PDGF/PDGFR pathway as a drug target
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-5781-5524
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2018 (English)In: Molecular Aspects of Medicine, ISSN 0098-2997, E-ISSN 1872-9452, Vol. 62, p. 75-88Article, review/survey (Refereed) Published
Abstract [en]

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations or activating chromosomal translocations. Current development of therapeutic drugs often aims at producing compounds that specifically target interaction between PDGFs and their receptors by specific DNA aptamers and ligand traps, or downregulate PDGFRs with blocking antibodies, or inhibit tyrosine kinase activity of PDGFRs with small molecules. In this review, we discuss some of the approaches taken to interfere with PDGF signaling, review a panel of existing therapeutic drugs, and consider clinically successful cases and remaining challenges.

Place, publisher, year, edition, pages
2018. Vol. 62, p. 75-88
Keywords [en]
PDGF pathway, PDGFR, Therapeutics, Drug targeting
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-365117DOI: 10.1016/j.mam.2017.11.007ISI: 000435085900007PubMedID: 29137923OAI: oai:DiVA.org:uu-365117DiVA, id: diva2:1262637
Available from: 2018-11-12 Created: 2018-11-12 Last updated: 2018-11-12Bibliographically approved

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Papadopoulos, NataliaLennartsson, Johan

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Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabDepartment of Pharmaceutical Biosciences
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