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The Genesis of the Neuroendocrine Tumors Concept: From Oberndorfer to 2018
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Tumor Biology.ORCID iD: 0000-0002-3432-1182
2018 (English)In: Endocrinology and metabolism clinics of North America (Print), ISSN 0889-8529, E-ISSN 1558-4410, Vol. 47, no 3, p. 711-731Article in journal (Refereed) Published
Abstract [en]

The concept of neuroendocrine tumors (NETs) began in the 1900s with Oberndorfer's description of carcinoid tumors, followed by specific cytotoxic agents and the identification of somatostatin. NETs diagnosis was confirmed by World Health Organization classification. Histopathology included immunohistochemistry with specific antibodies. Imaging was refined with molecular imaging. Somatostatin is the leading agent for controlling clinical symptoms related to hormone production. Increasing interest in these tumors, previously thought rare, led to increased incidence and prevalence. Between 1960 and 1970, the true NET concept was established with the development of radioimmunoassays for peptides and hormones and imaging with computerized tomography.

Place, publisher, year, edition, pages
2018. Vol. 47, no 3, p. 711-731
Keywords [en]
NET, Biomarker, Imaging, Somatostatin analogues, Chemotherapy, PRRT, Targeted agents
National Category
Endocrinology and Diabetes Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-365662DOI: 10.1016/j.ecl.2018.05.003ISI: 000444367100019PubMedID: 30098726OAI: oai:DiVA.org:uu-365662DiVA, id: diva2:1263350
Available from: 2018-11-15 Created: 2018-11-15 Last updated: 2018-11-15Bibliographically approved

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