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Low-Frequency Stimulation of Silent Nociceptors Induces Secondary Mechanical Hyperalgesia in Human Skin
Univ Erlangen Nurnberg, Dept Physiol & Expt Pathophysiol, Nurnberg, Germany; Heidelberg Univ, Med Fac Mannheim, Dept Expt Pain Res, CBTM, Mannheim, Germany.
Univ Erlangen Nurnberg, Dept Physiol & Expt Pathophysiol, Nurnberg, Germany; Heidelberg Univ, Med Fac Mannheim, Dept Expt Pain Res, CBTM, Mannheim, Germany.
Univ Erlangen Nurnberg, Dept Physiol & Expt Pathophysiol, Nurnberg, Germany; Heidelberg Univ, Med Fac Mannheim, Dept Expt Pain Res, CBTM, Mannheim, Germany.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
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2018 (English)In: Neuroscience, ISSN 0306-4522, E-ISSN 1873-7544, Vol. 387, p. 4-12Article in journal (Refereed) Published
Abstract [en]

Secondary mechanical hyperalgesia to punctate mechanical stimuli and light touch (allodynia) are prominent symptoms in neuropathic pain states. In a combined microneurographic and psychophysical study, we investigated the role of mechano-insensitive (silent) nociceptors regarding induction. Electrical thresholds of mechano-sensitive and silent nociceptors were assessed by microneurography with two closely spaced intracutaneous electrodes (i.c.) and a transcutaneous configuration (t.c.) in the foot dorsum. For t.c. stimulation there was a marked difference between silent (median, quartiles; 60, 50-70 mA, n = 63) and mechano-sensitive fibers (3, 2-5 mA, n = 107). In silent fibers, thresholds were lower for i.c. stimulation (16, 14-19 mA, n = 8), but higher in mechano-sensitive units (6, 5-6 mA, n = 13). Corresponding psychophysical tests showed no difference between the stimulation configuration for pain thresholds, but lower thresholds for the i.c. stimulation in axon reflex erythema (12 vs. 21 mA), punctate hyperalgesia (9 vs. 15 mA) and allodynia (15 vs. 18 mA). Punctate hyperalgesia was evoked at very low stimulation frequencies of 1/20 Hz (7/7 subjects), whereas the induction of an axon reflex flare required stimulation at 1/5 Hz. Electrical stimulation which is sufficient to excite mechano-insensitive C nociceptors can induce secondary mechanical hyperalgesia even at low frequencies supporting a role of such low-level input to clinical pain states. Thus, differential nociceptor class-specific input to the spinal cord adds to the complexity of modulatory mechanisms that determine nociceptive processing in the spinal cord.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2018. Vol. 387, p. 4-12
Keywords [en]
pain, sensitization, flare, neurogenic inflammation, punctate hyperalgesia, allodynia
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-366272DOI: 10.1016/j.neuroscience.2018.03.006ISI: 000445102800002PubMedID: 29551562OAI: oai:DiVA.org:uu-366272DiVA, id: diva2:1265723
Funder
German Research Foundation (DFG), SFB 1158Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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