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Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells
Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden;Karolinska Univ Hosp, Hematol Ctr, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.ORCID iD: 0000-0003-3007-9875
2018 (English)In: BLOOD ADVANCES, ISSN 2473-9529, Vol. 2, no 17, p. 2273-2281Article, review/survey (Refereed) Published
Abstract [en]

Hematopoietic stem cells differentiate into all types of blood cells, including peripheral tissue-resident mast cells. The early mast cell differentiation takes place in the bone marrow, after which the progenitor cells enter the circulation and mature once reaching their target organ. Early results from single-cell culture experiments and colony-forming assays have produced the classic hierarchical tree model of hematopoiesis. The introduction of high-throughput, single-cell RNA sequencing is now revolutionizing our understanding of the differentiation process, questioning the classic tree-based models. By integrating the results from early cell culture experiments with single-cell transcriptomics, we present a differentiation landscape model of hematopoiesis and discuss it with focus on mast cells. The review also describes how the hematologic neoplasm systemic mastocytosis can be used to model human hematopoiesis using naturally occurring cell barcoding by means of the common KIT D816V mutation.

Place, publisher, year, edition, pages
AMER SOC HEMATOLOGY , 2018. Vol. 2, no 17, p. 2273-2281
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-367138DOI: 10.1182/bloodadvances.2018019539ISI: 000444247300012PubMedID: 30206100OAI: oai:DiVA.org:uu-367138DiVA, id: diva2:1266778
Funder
Swedish Research CouncilSwedish Cancer SocietyTore Nilsons Stiftelse för medicinsk forskningMagnus Bergvall FoundationAvailable from: 2018-11-29 Created: 2018-11-29 Last updated: 2018-11-29Bibliographically approved

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