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Microalbuminuria measured by three different methods, blood pressure and cardiovascular risk factors in elderly Swedish males
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biologisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biologisk struktur och funktion)
2008 (English)In: Analytical chemistry insights, ISSN 1177-3901, Vol. 3, 69-74 p.Article in journal (Refereed) Published
Abstract [en]

Microalbuminuria is associated with hypertension and is a strong risk factor for subsequent chronic disease, both renal and coronary heart disease (CHD), Presently there are several methods available for measurement of microalbuminuria. The aim of this study was to evaluate if the three different methods gave similar information or if one of the assays were superior to the others. Blood pressure, infl ammatory markers and cardiovascular mortality and morbidity were correlated with urine albumin analysed with a point-of-care testing (POCT) instrument, nephelometric determination of albumin and albumin/creatinine ratio in elderly males. The study population consisted of 103 diabetic and 603 nondiabetic males (age 77 years) in a cross-sectional study. We analyzed urine albumin with a HemoCue® Urine Albumin POCT instrument and a ProSpec® nephelometer and albumin/creatinine ratio. There were strong correlations between both systolic and diastolic blood pressure and all three urine albumin methods (p < 0.0001). There were also signifi cant correlations between the different urine albumin measurements and serum amyloid A component, high-sensitivity C-reactive protein and interleukin-6. The three different urine albumin methods studied provided similar information in relation to cardiovascular disease. There was a strong correlation between systolic and diastolic blood pressure and microalbuminuria in both the whole study population and in nondiabetic males emphasizing the role of hypertension in glomerular damage. The good correlation between the studied urine albumin measurements show that all three methods can be used for monitoring urine albumin excretion.

Place, publisher, year, edition, pages
2008. Vol. 3, 69-74 p.
Keyword [en]
Age, Cardiovascular disease, C-reactive protein, Hypertension, IL-6, Infl ammation, Microalbuminuria
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-86635OAI: oai:DiVA.org:uu-86635DiVA: diva2:126717
Available from: 2008-11-24 Created: 2008-11-20 Last updated: 2009-07-03Bibliographically approved

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Larsson, Anders

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