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Chemical micropatterning of hyaluronic acid hydrogels for controlled cell adhesion
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD:  0000-0001-5952-2418
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. (EMBLA)ORCID iD: 0000-0002-1264-1337
2018 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

The blood brain barrier is constituted by endothelial cells, astrocytes and pericytes; and are organized into well structured units [1]. Standard cell culture techniques cannot recapitulate this organized structure. Hydrogels are an attractive scaffold due to their mechanical and chemical properties similar to those in body tissue[2] We propose the use of a photo-crosslinkable hyaluronic acid hydrogel as cell culture scaffold. Furthermore, chemical cues can be added into the hydrogel matrix to promote and control cell adhesion using UV lithography.

Place, publisher, year, edition, pages
2018.
National Category
Engineering and Technology Other Medical Engineering
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-368272OAI: oai:DiVA.org:uu-368272DiVA, id: diva2:1268225
Conference
European Organ on Chip, Stuttgart, Germany 24-25 May, 2018
Funder
Wallenberg Foundations, 2016-0112EU, Horizon 2020, 757444Available from: 2018-12-05 Created: 2018-12-05 Last updated: 2018-12-11Bibliographically approved

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Porras, Ana MariaShi, LiyangOssipov, Dmitri A.Tenje, Maria

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