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Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 years
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
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2008 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, no 97, 1691-1697 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To assess final height in children with growth hormone deficiency (GHD) treated with human recombinant growth hormone (GH).

Methods: Final height data for 401 Swedish children with idiopathic GHD and treated with GH, included in KIGS (Pfizer International Growth Database) between 1987 and spring 2006, were analysed retrospectively. Data were grouped according to sex, age and severity of GHD. Height at entry into KIGS, at the onset of puberty and near final height were analysed between groups.

Results: Groups were heterogeneous for GHD, which ranged from partial to severe. For all groups, mean final height corrected for mid-parental height was within the normal Swedish height range. In patients with severe GHD, mean final height was almost identical to mean normal Swedish height. About 16% of patients showed disproportionality (short legs) at final height and were significantly shorter than other patients. The parents of these children also demonstrated short stature.

Conclusion: Children with idiopathic GHD receiving GH replacement therapy can achieve a final height that as a group is within the normal range and all achieve a height within their genetic potential.

Place, publisher, year, edition, pages
2008. no 97, 1691-1697 p.
Keyword
adolescence, body compartments, DXA, energy expenditure
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-86687DOI: 10.1111/j.1651-2227.2008.01035.xISI: 000260731300022OAI: oai:DiVA.org:uu-86687DiVA: diva2:126955
Available from: 2008-12-03 Created: 2008-11-26 Last updated: 2017-12-14Bibliographically approved

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