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Influence of fractal surface dimension on the dissolution process of sparingly soluble CaCO3 microparticles
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.ORCID iD: 0000-0002-5496-9664
2009 (English)In: Applied Physics A: Materials Science & Processing, ISSN 0947-8396, E-ISSN 1432-0630, Vol. 94, no 2, 299-305 p.Article in journal (Refereed) Published
Abstract [en]

The dissolution process of sparingly soluble CaCO3 microparticles and how the fractal surface dimension of the particles changes during dissolution is analyzed. The particles and the dissolution process are studied using scanning electron microscopy, X-ray diffraction, nitrogen adsorption, laser diffraction and conductance measurements. Ball milling of the particles is shown to maintain the particle crystallinity, and to introduce an increased fractal surface dimension in the 1–10 μm size range. Dissolution is found to increase the surface dimension of initially smooth particles and to maintain the fractal surface roughness of milled particles. The dissolution process increases the relative number of small particles (50 nm–1 μm) whereas the larger ones decrease in size. The solubility of the milled fractal particles was ∼1.8 times higher than that for the initially smooth ones. The presented findings show that developing methods for increasing the fractal surface roughness of particles should be of interest for improving the solubility of poorly soluble drug candidates.

Place, publisher, year, edition, pages
2009. Vol. 94, no 2, 299-305 p.
Keyword [en]
61.46.-w; 81.05.-t
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-86725DOI: 10.1007/s00339-008-4792-8ISI: 000261257100015OAI: oai:DiVA.org:uu-86725DiVA: diva2:127088
Available from: 2008-12-01 Created: 2008-11-30 Last updated: 2017-12-14Bibliographically approved

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Mihranyan, AlbertStrömme, Maria

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