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Elongation Factors: Translation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2017 (English)In: Reference Module in Life Sciences, Elsevier, 2017Chapter in book (Other academic)
Abstract [en]

Translation elongation factors perform critical functions in protein synthesis in all domains of life, including the delivery of aminoacyl-tRNAs into the ribosome, and the translocation of peptidyl-tRNA from the ribosomal A-site to the ribosomal P-site. Elongation factor Tu (EF-Tu, EF1-alpha) is a GTP-binding protein that is responsible for carrying each aminoacyl-tRNA to the ribosome, a process that involves hydrolysis of GTP and dissociation of the complex. EF-Ts is responsible for exchanging GDP for GTP on EF-Tu, ensuring that EF-Tu is reactivated for aminoacyl-tRNA binding after interacting with the ribosome. A third factor, EF-G (EF2 in eukaryotes), is responsible for catalyzing the translocation of peptidyl-tRNA from the A-site to the P-site. The elongation factors EF-Tu and EF-G are targets for several natural antibiotics, including fusidic acid (targets EF-G) which is used clinically to treat infections by Staphylococcus aureus.

Place, publisher, year, edition, pages
Elsevier, 2017.
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-371260DOI: 10.1016/B978-0-12-809633-8.06378-0OAI: oai:DiVA.org:uu-371260DiVA, id: diva2:1272886
Note

Revised version of: D. Hughes: Elongation Factors. Brenner's Encyclopedia of Genetics, 2013, Pages 466-468  (https://doi.org/10.1016/B978-0-12-374984-0.00468-X)

Available from: 2018-12-20 Created: 2018-12-20 Last updated: 2019-05-23Bibliographically approved

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