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Cytokines regulating lymphangiogenesis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
2018 (English)In: Current Opinion in Immunology, ISSN 0952-7915, E-ISSN 1879-0372, Vol. 53, p. 58-63Article, review/survey (Refereed) Published
Abstract [en]

Lymphatic vessels are established by differentiation of lymphendothelial progenitors during embryogenesis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing ones is rare in the healthy adult but takes place during pathological conditions such as inflammation, tissue repair and tumor growth. Conditions of dysfunctional lymphatics exist after surgical interventions or in certain genetic diseases. A key lymphangiogenic stimulator is vascular endothelial growth factor-C (VEGFC) acting on VEGF receptor-3 (VEGFR3) expressed on lymphendothelial cells. Other cytokines may act directly to regulate lymphangiogenesis positively or negatively, or indirectly by inducing expression of VEGFC. This review describes different known lymphangiogenic cytokines, their mechanism of action and role in lymphangiogenesis in health and disease.

Place, publisher, year, edition, pages
CURRENT BIOLOGY LTD , 2018. Vol. 53, p. 58-63
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-370056DOI: 10.1016/j.coi.2018.04.003ISI: 000448096600011PubMedID: 29680577OAI: oai:DiVA.org:uu-370056DiVA, id: diva2:1273287
Funder
Swedish Research Council, 2015-02375_3Knut and Alice Wallenberg FoundationSwedish Cancer Society, 16 0585Available from: 2018-12-20 Created: 2018-12-20 Last updated: 2018-12-20Bibliographically approved

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Sainz-Jaspeado, MiguelClaesson-Welsh, Lena

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