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Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastase
Helsingborg Hosp, Dept Surg, Helsingborg, Sweden; Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, Lund, Sweden.
Dept Genet & Pathol, Lab Med, Lund, Sweden.
Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, Lund, Sweden.
Lund Univ, Dept Clin Sci Lund, Div Oncol & Pathol, Lund, Sweden; Dept Genet & Pathol, Lab Med, Lund, Sweden.
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2018 (English)In: American Journal of Clinical Pathology, ISSN 0002-9173, E-ISSN 1943-7722, Vol. 150, no 6, p. 533-544Article in journal (Refereed) Published
Abstract [en]

Objectives: Immunohistochemical staining against thyroid transcription factor 1 (TTF-1) is often used to distinguish lung adenocarcinoma from squamous cell carcinoma and pulmonary metastasis.

Methods: TTF-1 expression was examined using the antibody clones 8G7G3/1, SPT24, and SP141 on tissue microarrays from 665 cases of resected lung cancers and 428 pulmonary metastases.

Results: Most lung adenocarcinomas, 89%, 93%, and 93%, were positive with TTF-1 clones 8G7G3/1, SPT24, and SP141, respectively. The corresponding figures for lung squamous cell carcinomas were 0%, 6%, and 8%. In total, five (2%), 19 (7%), and 21 (8%) of the pulmonary metastases from colorectal adenocarcinomas were positive with clones 8G7G3/1, SPT24, and SP141, respectively. Other TTF-1-positive pulmonary metastases (n = 8) were thyroid, urothelial, pancreatic, small bowel, and cervix carcinomas.

Conclusions: TTF-1 expression in lung cancer and pulmonary metastases differs between clones, with 8G7G3/1 being more specific but less sensitive compared with SPT24 and SP141.

Place, publisher, year, edition, pages
2018. Vol. 150, no 6, p. 533-544
National Category
Clinical Laboratory Medicine
Research subject
Pathology
Identifiers
URN: urn:nbn:se:uu:diva-372014DOI: 10.1093/ajcp/aqy083ISI: 000456564300008PubMedID: 30169783OAI: oai:DiVA.org:uu-372014DiVA, id: diva2:1275120
Available from: 2019-01-04 Created: 2019-01-04 Last updated: 2019-03-29Bibliographically approved

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Mattsson, Johanna Sofia MargaretaBotling, JohanMicke, Patrick

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