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Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata.
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2012 (English)In: Planta Medica, ISSN 0032-0943, E-ISSN 1439-0221, Vol. 78, no 1, p. 31-5Article in journal (Refereed) Published
Abstract [en]

The dichloromethane/methanol (1:1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC(50) = 0.9-3 µg/mL) IN VITRO antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of PLASMODIUM FALCIPARUM. Chromatographic separation of the extract of PENTAS LONGIFLORA led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC(50) values below 1 µg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones ( 4-11, IC(50) = 5-31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three--nordamnacanthal (7), lucidin-ω-methyl ether (9), and damnacanthol (10)--are reported here for the first time from the genus Pentas. The compounds were identified by NMR and mass spectroscopic techniques.

Place, publisher, year, edition, pages
2012. Vol. 78, no 1, p. 31-5
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Organic Chemistry
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URN: urn:nbn:se:uu:diva-369292DOI: 10.1055/s-0031-1280179PubMedID: 21979929OAI: oai:DiVA.org:uu-369292DiVA, id: diva2:1275518
Available from: 2019-01-06 Created: 2019-01-06 Last updated: 2019-08-07Bibliographically approved

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Erdélyi, Máté

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