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Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study
Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers, CCBIO, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, Norway.
Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers, CCBIO, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, Norway.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Haukeland Hosp, Dept Radiol, Ctr Nucl Med PET, Bergen, Norway;Haukeland Hosp, Dept Radiol, Bergen, Norway.
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2018 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 125, no 13, p. 1695-1703Article in journal (Refereed) Published
Abstract [en]

Objective Design Correct preoperative identification of high-risk patients is important to optimise surgical treatment and improve survival. We wanted to explore if asparaginase-like protein 1 (ASRGL1) expression in curettage could predict lymph node metastases and poor outcome, potentially improving preoperative risk stratification. Multicentre study. Setting Population Ten hospitals in Norway, Sweden and Belgium. Women diagnosed with endometrial carcinoma. Methods Main outcome measures ASRGL1 expression in curettage specimens from 1144 women was determined by immunohistochemistry. ASRGL1 status related to disease-specific survival, lymph node status, preoperative imaging parameters and clinicopathological data. Results Conclusions ASRGL1 expression had independent prognostic value in multivariate survival analyses, both in the whole patient population (hazard ratio (HR) 1.63, 95% CI 1.11-2.37, P = 0.012) and in the low-risk curettage histology subgroup (HR 2.54, 95% CI 1.44-4.47, P = 0.001). Lymph node metastases were more frequent in women with low expression of ASRGL1 compared with women with high ASRGL1 levels (23% versus 10%, P < 0.001), and low ASRGL1 level was found to independently predict lymph node metastases (odds ratio 2.07, 95% CI 1.27-3.38, P = 0.003). Low expression of ASRGL1 in curettage independently predicts lymph node metastases and poor disease-specific survival.

Place, publisher, year, edition, pages
2018. Vol. 125, no 13, p. 1695-1703
Keywords [en]
Asparaginase-like protein 1, biomarker, curettage, endometrial carcinoma
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-371035DOI: 10.1111/1471-0528.15403ISI: 000450069000016PubMedID: 29989298OAI: oai:DiVA.org:uu-371035DiVA, id: diva2:1275555
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-08Bibliographically approved

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Edqvist, Per-Henrik D

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