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Not so lost in translation: RPS15 mutations in CLL
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
Karolinska Inst, Stockholm, Sweden.
2018 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 132, no 22, p. 2317-2319Article in journal, Editorial material (Other academic) Published
Abstract [en]

In this issue of Blood, Bretones et al expand knowledge of the functional consequences of recurrent mutations in RPS15, a gene that encodes a ribosomal protein of the 40S subunit and is enriched in patients with clinically aggressive chronic lymphocytic leukemia (CLL).(1) By transfecting RPS15 mutants and applying different technologies to assess ribosome activity and efficiency in combination with high-throughput proteome profiling, they were able to demonstrate reduced half-life of RPS15, impaired translational fidelity, and changes in the expressed proteome in mutant vs wild-type RPS15.

Place, publisher, year, edition, pages
AMER SOC HEMATOLOGY , 2018. Vol. 132, no 22, p. 2317-2319
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Hematology
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URN: urn:nbn:se:uu:diva-372515DOI: 10.1182/blood-2018-09-875179ISI: 000451634400003PubMedID: 30498067OAI: oai:DiVA.org:uu-372515DiVA, id: diva2:1276729
Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-08Bibliographically approved

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Ljungström, Viktor

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