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Elevated exhaled nitric oxide in adolescents relates to incident allergic symptoms: a prospective cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.ORCID iD: 0000-0001-5180-5026
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.ORCID iD: 0000-0001-5093-6980
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
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2019 (English)In: Journal of investigational allergology & clinical immunology, ISSN 1018-9068, E-ISSN 1698-0808, Vol. 29, no 3, p. 231-238Article in journal (Refereed) Published
Abstract [en]

Background: The fraction of exhaled nitric oxide (FeNO) is a marker of type-2 inflammation in the airways and elevated FeNO may precede development of allergic disease. The aim of the present study was to investigate the association between elevated FeNO and the development of allergic symptoms.

Methods: A total of 959 adolescents from a general population answered, together with their parents, a standardized questionnaire, performed lung function and FeNO measurements at a baseline visit. Four years later, 921 of these subjects (96%) completed a to a great extent same version of the baseline questionnaire.

Results: Adolescents with self-reported incident allergic symptoms to cat (n = 50) or dog (n = 33) had higher baseline FeNO (p < 0.001) than subjects without allergic symptoms to cat and dog at either time point (n = 776 and n = 838, respectively). Adolescents with incident allergic symptoms to pollen did not have elevated baseline FeNO. The adjusted odds ratio [aOR (95% confidence interval)] for incident allergic symptoms to cat was 4.2 (2.2, 8.0) times higher if FeNO was > 75th percentile (vs. < 75th percentile) at baseline. This was consistent after exclusion of subjects with reported asthma, wheeze or rhinitis at baseline [aOR (95% CI) 8.6 (3.0, 24.1)].

Conclusion: Elevated FeNO in adolescents related to an increased risk of developing allergic symptoms to cat and dog, but not pollen allergens, within four years.

Place, publisher, year, edition, pages
ESMON Publicidad , 2019. Vol. 29, no 3, p. 231-238
Keywords [en]
Adolescents, Breath test, Epidemiology, Hypersensitivity, Incident, Nitric oxide
National Category
Public Health, Global Health, Social Medicine and Epidemiology Pediatrics Respiratory Medicine and Allergy
Research subject
Clinical Physiology
Identifiers
URN: urn:nbn:se:uu:diva-372786DOI: 10.18176/jiaci.0317ISI: 000472145600006PubMedID: 30183659OAI: oai:DiVA.org:uu-372786DiVA, id: diva2:1276824
Funder
AstraZenecaÅke Wiberg FoundationSwedish Foundation for Strategic Research , RB13-0196Swedish Heart Lung Foundation, 20150609; 20160618Swedish Asthma and Allergy Association, F2016-0045Available from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-08-05Bibliographically approved

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Kalm-Stephens, PiaNordvall, LennartJanson, ChristerNeuman, ÅsaMalinovschi, AndreiAlving, Kjell

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Journal of investigational allergology & clinical immunology
Public Health, Global Health, Social Medicine and EpidemiologyPediatricsRespiratory Medicine and Allergy

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