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Reference intervals for reticulocyte hemoglobin content in healthy infants
Hosp Halland, Dept Pediat, Halmstad, Sweden.
Umea Univ, Dept Clin Sci, Pediat, Umea, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Perinatal, Neonatal and Pediatric Cardiology Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Child Health and Nutrition. Hosp Halland, Dept Pediat, Halmstad, Sweden.ORCID iD: 0000-0002-3972-0457
2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 84, no 5, p. 657-661Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. METHODS: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48-72 h, 4 months, and 12 months. Reference intervals were calculated as +/- 2 standard deviations from the mean of Ret-He. RESULTS: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1-37.7 pg/L (N = 253) at 48-72 h, 25.6-33.4 pg/L (N = 341) at four months and 24.9-34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% Cl) -4.2 pg/L (-6.1 to -2.4) and at 12 months mean difference (95% Cl) -3.4 pg/L (-5.0 to -1.8). CONCLUSIONS: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 84, no 5, p. 657-661
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-372830DOI: 10.1038/s41390-018-0046-4ISI: 000453019100021PubMedID: 30140071OAI: oai:DiVA.org:uu-372830DiVA, id: diva2:1276885
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-01-09Bibliographically approved

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Hellström-Westas, LenaAndersson, Ola

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