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Prenatal exposures and birth indices, and subsequent risk of polycystic ovary syndrome: a national registry-based cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Clinical Obstetrics.ORCID iD: 0000-0002-7926-5583
Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Obstet & Gynaecol, Trondheim, Norway;Norwegian Univ Sci & Technol, Dept Lab Med Childrens & Womens Hlth, Trondheim, Norway.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.ORCID iD: 0000-0002-2491-2042
Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden.
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2019 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 126, no 2, p. 244-251Article in journal (Refereed) Published
Abstract [en]

Objective: To study the associations between prenatal exposures and risk of developing polycystic ovary syndrome (PCOS).

Design: National registry-based cohort study.

Setting: Sweden.

Population: Girls born in Sweden during the years 1982-1995 (n = 681 123).

Methods: The girls were followed until the year 2010 for a diagnosis of PCOS. We estimated the associations between maternal body mass index (BMI), smoking, and size at birth with the risk of developing a PCOS diagnosis. Risks were calculated by adjusted hazard ratio (aHR) and 95% confidence intervals (95% CIs). Main outcome measures A diagnosis of PCOS at 15 years of age or later.

Results: During the follow-up period 3738 girls were diagnosed with PCOS (0.54%). Girls with mothers who were overweight or obese had 1.5-2.0 times higher risk of PCOS (aHR 1.52, 95% CI 1.36-1.70; aHR 1.97, 95% CI 1.61-2.41, respectively), compared with girls born to mothers of normal weight. The risk of PCOS was increased if the mother smoked during pregnancy (1-9 cigarettes/day, aHR 1.31, 95% CI 1.18-1.47; >= 10 cigarettes/day, aHR 1.44, 95% CI 1.27-1.64). Being born small for gestational age (SGA) was associated with a later diagnosis of PCOS in crude estimates, but the association was not significant after adjusting for maternal factors.

Conclusions: Maternal smoking and increased BMI appear to increase the risk of PCOS in offspring. The association between SGA and the development of PCOS appears to be mediated by maternal factors.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 126, no 2, p. 244-251
Keywords [en]
Birthweight, body mass index, polycystic ovary syndrome, prenatal care, smoking
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-372879DOI: 10.1111/1471-0528.15236ISI: 000452871600023PubMedID: 29896923OAI: oai:DiVA.org:uu-372879DiVA, id: diva2:1277270
Funder
Swedish Research Council, 2013-2429Swedish Research Council, 2014-3561Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-04-25Bibliographically approved

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Valgeirsdóttir, HeiddisSundström Poromaa, IngerWikström, Anna-Karin

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