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Circulating microRNA plasma profile in MuSK plus myasthenia gravis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Duke Univ, Dept Neurol, Durham, NC USA.
Duke Univ, Dept Neurol, Durham, NC USA.
Duke Univ, Dept Neurol, Durham, NC USA.
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2018 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 325, p. 87-91Article in journal (Refereed) Published
Abstract [en]

Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK + MG. From the discovery cohort miR-210-3p, miR-3243p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 +/- 1.4 vs 5.1 +/- 1.4, p = .006 and 4.7 +/- 1.0 vs 5.4 +/- 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.

Place, publisher, year, edition, pages
2018. Vol. 325, p. 87-91
Keywords [en]
Muscle-specific tyrosine kinase, MuSK, Myasthenia gravis, microRNA, Biomarker
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-372925DOI: 10.1016/j.jneuroim.2018.10.003ISI: 000452932200013PubMedID: 30316681OAI: oai:DiVA.org:uu-372925DiVA, id: diva2:1277473
Funder
Swedish Research Council, VR-523-2014-2048Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-01-10Bibliographically approved

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Sabre, LiisRostedt Punga, Anna

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