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Host specificity in the Giardia duodenalis species complex
Ist Super Sanita, Dept Infect Dis, Viale Regina Elena 299, I-00161 Rome, Italy.
Ist Super Sanita, Dept Infect Dis, Viale Regina Elena 299, I-00161 Rome, Italy.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
2018 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 66, p. 335-345Article, review/survey (Refereed) Published
Abstract [en]

Giardia duodenalis is a unicellular flagellated parasite that infects the gastrointestinal tract of a wide range of mammalian species, including humans. Investigations of protein and DNA polymorphisms revealed that G. duodenalis should be considered as a species complex, whose members, despite being morphologically indistinguishable, can be classified into eight groups, or Assemblages, separated by large genetic distances. Assemblages display various degree of host specificity, with Assemblages A and B occurring in humans and many other hosts, Assemblage C and D in canids, Assemblage E in hoofed animals, Assemblage F in cats, Assemblage G in rodents, and Assemblage H in pinnipeds. The factors determining host specificity are only partially understood, and clearly involve both the host and the parasite. Here, we review the results of in vitro and in vivo experiments, and clinical observations to highlight relevant biological and genetic differences between Assemblages, with a focus on human infection.

Place, publisher, year, edition, pages
2018. Vol. 66, p. 335-345
Keywords [en]
Giardia duodenalis, Host specificity, Host-parasite interactions, In vivo models, Genomics
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-373081DOI: 10.1016/j.meegid.2017.12.001ISI: 000452589900043PubMedID: 29225147OAI: oai:DiVA.org:uu-373081DiVA, id: diva2:1277931
Funder
Swedish Research CouncilAvailable from: 2019-01-11 Created: 2019-01-11 Last updated: 2019-01-11Bibliographically approved

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