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Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer
Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, POB 9101, NL-6500 HB Nijmegen, Netherlands.
Univ Libre Bruxelles, Fac Med, ULB Ctr Diabet Res, Brussels, Belgium.
Ctr Pediat & Adolescent Diabet Care & Res, Diabeter, Rotterdam, Netherlands.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.ORCID iD: 0000-0002-8524-9547
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2018 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 12, p. 2516-2519Article in journal (Refereed) Published
Abstract [en]

In this issue of Diabetologia, Alavi and Werner (10.1007/s00125-018-4676-1) criticise the attempts to use positron emission tomography (PET) for in vivo imaging of pancreatic beta cells, which they consider as futile'. In support of this strong statement, they point out the limitations of PET imaging, which they believe render beta cell mass impossible to estimate using this method. In our view, the Alavi and Werner presentation of the technical limitations of PET imaging does not reflect the current state of the art, which leads them to questionable conclusions towards the feasibility of beta cell imaging using this approach. Here, we put forward arguments in favour of continuing the development of innovative technologies enabling in vivo imaging of pancreatic beta cells and concisely present the current state of the art regarding putative technical limitations of PET imaging. Indeed, far from being a futile' effort, we demonstrate that beta cell imaging is now closer than ever to becoming a long-awaited clinical reality.

Place, publisher, year, edition, pages
SPRINGER , 2018. Vol. 61, no 12, p. 2516-2519
Keywords [en]
Clinical diabetes, Imaging, Islets, PET imaging
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-369382DOI: 10.1007/s00125-018-4745-5ISI: 000449290200005PubMedID: 30284016OAI: oai:DiVA.org:uu-369382DiVA, id: diva2:1278729
Available from: 2019-01-15 Created: 2019-01-15 Last updated: 2019-01-15Bibliographically approved

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Korsgren, OlleEriksson, Olof

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