uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Salicylate induces anxiety-like behavior and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil.
Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil.
Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil.
Univ Fed Rio Grande do Norte, Inst Brain, Neurodynam Lab, Natal, RN, Brazil.
Show others and affiliations
2019 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 29, no 1, p. 15-25Article in journal (Refereed) Published
Abstract [en]

Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus-like perception in animal models. Here, we assess whether salicylate induces anxiety-like electrophysiological and behavioral signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hr after salicylate (300 mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate-treated animals showed a strong 4-6 Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4-6 Hz-theta band was low in the ventral and dorsal hippocampus when compared to movement-related theta coherence (7-10 Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate-induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety-like behaviors. Here, we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 29, no 1, p. 15-25
Keywords [en]
anxiety, salicylate, theta, tinnitus, ventral hippocampus
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-373310DOI: 10.1002/hipo.23021ISI: 000454153200002PubMedID: 30152905OAI: oai:DiVA.org:uu-373310DiVA, id: diva2:1279443
Available from: 2019-01-16 Created: 2019-01-16 Last updated: 2019-01-16Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Mikulovic, SanjaLeão, Richardson N

Search in DiVA

By author/editor
Mikulovic, SanjaLeao, Katarina E.Leão, Richardson N
By organisation
Department of Neuroscience
In the same journal
Hippocampus
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 8 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf