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Thromboinflammation in Therapeutic Medicine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Linnæus Center of Biomaterials Chemistry, Linnæus University, Kalmar, Sweden.
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2015 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 865, p. 3-17Article, review/survey (Refereed) Published
Abstract [en]

Thromboinflammation is primarily triggered by the humoral innate immune system, which mainly consists of the cascade systems of the blood, i.e., the complement, contact/coagulation and fibrinolytic systems. Activation of these systems subsequently induces activation of endothelial cells, leukocytes and platelets, finally resulting in thrombotic and inflammatory reactions. Such reactions are triggered by a number of medical procedures, e.g., treatment with biomaterials or drug delivery devices as well as in transplantation with cells, cell clusters or whole vascularized organs. Here, we (1) describe basic mechanisms for thromboinflammation; (2) review thromboinflammatory reactions in therapeutic medicine; and (3) discuss emerging strategies to dampen thromboinflammation.

Place, publisher, year, edition, pages
2015. Vol. 865, p. 3-17
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-373997DOI: 10.1007/978-3-319-18603-0_1PubMedID: 26306440OAI: oai:DiVA.org:uu-373997DiVA, id: diva2:1279903
Available from: 2019-01-17 Created: 2019-01-17 Last updated: 2019-01-21Bibliographically approved

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Nilsson Ekdahl, KristinaAsif, SanaMagnusson, PeetraNilsson, Bo

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Clinical ImmunologyDepartment of Immunology, Genetics and Pathology
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