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Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)
Haukeland Hosp, Dept Oncol & Clin Sci, Bergen, Norway.
Gustave Roussy, Endocrine Oncol, Villejuif, France.
Clin Univ St Luc, Hepato Gastroenterol Unit, Brussels, Belgium.
Royal Free Hosp, Neuroendocrine Tumour Unit, Ctr Gastroenterol, London, England.
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2019 (English)In: Neuroendocrinology, ISSN 0028-3835, E-ISSN 1423-0194, Vol. 108, no 1, p. 54-62Article in journal (Refereed) Published
Abstract [en]

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been shown to be a quite heterogeneous patient group concerning prognosis and treatment benefit, depending on factors such as the primary tumor site, differentiation, proliferation rate, and molecular alterations. In this review we discuss the existing data on diagnostics, treatment, and biomarkers in this patient group, the unmet needs, and the future perspectives.

Place, publisher, year, edition, pages
2019. Vol. 108, no 1, p. 54-62
Keywords [en]
Neuroendocrine carcinoma, Neuroendocrine neoplasm, Neuroendocrine tumor
National Category
Neurosciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-375598DOI: 10.1159/000493318ISI: 000456048400007PubMedID: 30153658OAI: oai:DiVA.org:uu-375598DiVA, id: diva2:1284259
Note

ENETS 2016 Munich Advisory Board, Uppsala University: Falkerby, Jenny; Sundin, Anders; Tiensuu Janson, Eva & Welin, Staffan.

Available from: 2019-01-31 Created: 2019-01-31 Last updated: 2019-02-11Bibliographically approved

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Welin, StaffanSundin, AndersTiensuu Janson, EvaWelin, Staffan

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