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Membrane interactions and cell selectivity of amphiphilic anticancer peptides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0001-5236-9107
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark.ORCID iD: 0000-0003-0046-5599
2018 (English)In: Current Opinion in Colloid & Interface Science, ISSN 1359-0294, E-ISSN 1879-0399, Vol. 38, p. 1-17Article, review/survey (Refereed) Published
Abstract [en]

Following considerable research efforts on antimicrobial effects by cationic and amphiphilic peptides during the last couple of decades, increasing focus has recently been placed on additional host defense and other biological functions by such peptides, such as anti-inflammatory and anticancer effects. Regarding the latter, it has been increasingly understood that amphiphilic peptides present interesting opportunities not only for reaching selective cancer cell toxicity, but also for promoting uptake of other anticancer therapeutics and of nanopariculate delivery systems containing such drugs. While there is an emerging understanding of the direct antimicrobial function of amphiphilic peptides through bacterial membrane destabilization, the mechanisms underlying their anticancer effects remain less clear. Here, we therefore provide a brief overview on factors affecting toxicity of amphiphilic peptides against tumor and non-malignant cells, and also describe how such peptides can be combined with conjugation moieties or drug delivery systems for increased anticancer effects.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE LONDON , 2018. Vol. 38, p. 1-17
Keywords [en]
Amphiphilic, Anticancer, Antimicrobial peptide, Membrane
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-374869DOI: 10.1016/j.cocis.2018.06.009ISI: 000455063600002OAI: oai:DiVA.org:uu-374869DiVA, id: diva2:1284262
Funder
Swedish Research Council, 2016-05157Available from: 2019-01-31 Created: 2019-01-31 Last updated: 2019-01-31Bibliographically approved

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Nyström, LinaMalmsten, Martin

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