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CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia
Univ Gothenburg, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden;Jiangsu Univ, Inst Life Sci, Zhenjiang, Peoples R China.ORCID iD: 0000-0003-1910-1234
Univ Gothenburg, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden.ORCID iD: 0000-0002-6472-2438
Guizhou Med Univ, Affiliated Hosp, Cent Lab, Guiyang, Guizhou, Peoples R China.
Univ Gothenburg, Dept Rheumatol & Inflammat Res, Box 480, SE-40530 Gothenburg, Sweden.ORCID iD: 0000-0001-9680-035X
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2019 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 184, no 3, p. 418-423Article in journal (Refereed) Published
Abstract [en]

Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2(,)(Re/Hi) and that high CD99 mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP-ALL.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 184, no 3, p. 418-423
Keywords [en]
BCP-ALL, CD99, biomarker, acute leukaemia, prognosis
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-376731DOI: 10.1111/bjh.15683ISI: 000456167900013PubMedID: 30484860OAI: oai:DiVA.org:uu-376731DiVA, id: diva2:1287171
Funder
Swedish Childhood Cancer Foundation, TJ2014-0083Swedish Childhood Cancer Foundation, TJ2016-0007Swedish Childhood Cancer Foundation, PR2016-0144Swedish Cancer Society, CAN2014/886Swedish Cancer Society, CAN2016/0668Available from: 2019-02-08 Created: 2019-02-08 Last updated: 2019-10-23Bibliographically approved

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Nordlund, JessicaLönnerholm, Gudmar

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Chen, DongfengCamponeschi, AlessandroGerasimcik, NatalijaNordlund, JessicaLönnerholm, Gudmar
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Molecular MedicineScience for Life Laboratory, SciLifeLabDepartment of Women's and Children's Health
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British Journal of Haematology
Hematology

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