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A clinical pharmacy intervention in the secondary prevention of coronary heart disease: The effect on adherence to cholesterol lowering medication
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2019 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Introduction: Cholesterol lowering medications for patient with coronary heart disease (CHD) reduces morbidity and mortality. The SWEDEHEART Annual report showed that only 60 % of Swedish patients on secondary prevention reached the treatment goal 2017. This could partly be explained by patients being non-adherent to their prescribed medications. In the randomized controlled study Motivational interviewing (MI) and medication review in coronary heart disease (MIMeRiC), clinical pharmacists interventions have been conducted, with the secondary objective of improving the adherence to cholesterol lowering medications.

Aim: The aim of this study was to determine if patient adherence to cholesterol lowering medication was affected by the interventions in the MIMeRiC-study.

Methods: Patients’ adherence was primary assessed with a combined measure of both self-reported adherence and refill adherence. Only one of the measures had to point out non-adherence, for a patient to be considered non‑adherent.

Results: In total, 288 patients were included (control:148, intervention:140). The proportion of adherent patients was 89 % (CI: 84-94) in the intervention group and 81 % (CI: 75-87) in the control group. No significant difference between groups could be noted with the significance level of p<0.05 (p-value = 0.051).

Conclusion: This study did not find any effect of MI and medication review on patients’ adherence. More research on the effects of MI and medication review on adherence with a larger number of patients will be needed.

Place, publisher, year, edition, pages
2019.
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-376759OAI: oai:DiVA.org:uu-376759DiVA, id: diva2:1287240
Educational program
Master of Science Programme in Pharmacy
Supervisors
Examiners
Available from: 2019-03-04 Created: 2019-02-09 Last updated: 2019-03-04Bibliographically approved

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CiteExportLink to record
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