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The BACHD rat model of Huntington disease shows slowed learning in a Go/No-Go-like test of visual discrimination
Univ Tubingen, Inst Med Genet & Appl Genom, Calwerstr 7, D-72076 Tubingen, Germany;Univ Tubingen, Ctr Rare Dis, D-72076 Tubingen, Germany;Lund Univ, Dept Expt Med Sci, Basal Ganglia Pathophysiol, Solvegatan 19,BMC F11, S-22184 Lund, Sweden.
Univ Tubingen, Inst Med Genet & Appl Genom, Calwerstr 7, D-72076 Tubingen, Germany;Univ Tubingen, Ctr Rare Dis, D-72076 Tubingen, Germany.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Tubingen, Inst Med Genet & Appl Genom, Calwerstr 7, D-72076 Tubingen, Germany;Univ Tubingen, Ctr Rare Dis, D-72076 Tubingen, Germany.ORCID iD: 0000-0002-6875-3928
Univ Tubingen, Inst Med Genet & Appl Genom, Calwerstr 7, D-72076 Tubingen, Germany;Univ Tubingen, Ctr Rare Dis, D-72076 Tubingen, Germany.
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2019 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 359, p. 116-126Article in journal (Refereed) Published
Abstract [en]

Huntington disease is a hereditary neurodegenerative disease, in which patients display a broad range of clinical symptoms. Among these, impaired inhibitory control has been noted. The BACHD rat is a recently developed and established transgenic animal model for Huntington disease, and characterizing the presence of Huntington disease-like behavioural phenotypes in these animals is of importance. Prior studies have indicated that BACHD rats suffer from impaired inhibitory control, although further studies are necessary to fully understand the scope and specific nature of these phenotypes. In the current study, BACHD rats were trained to perform a Go/No-Go-like test of visual discrimination, akin to behavioural tests that have revealed suspected response inhibition impairments in Huntington disease patients. The results indicate that although BACHD rats showed a slow rate of learning to inhibit responses on No-Go trials, once they had learned to handle the basic discrimination, they had an unchanged ability to withhold lever responses during extended periods of time. This suggests that BACHD rats have specific impairments when applying inhibitory control to a new or changed situation. The findings are in line with previous studies of BACHD rats and support the continued use and characterization of this animal model.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 359, p. 116-126
Keywords [en]
Huntington disease, BACHD rat, Cognitive deficits, Inhibitory control, Go/No-Go, Operant conditioning
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-376721DOI: 10.1016/j.bbr.2018.10.036ISI: 000456222600014PubMedID: 30385368OAI: oai:DiVA.org:uu-376721DiVA, id: diva2:1287531
Funder
EU, Horizon 2020, 643417Available from: 2019-02-11 Created: 2019-02-11 Last updated: 2019-02-11Bibliographically approved

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Clemensson, Laura Emily

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