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Genetic association between adiposity and gout: a Mendelian randomization study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.ORCID iD: 0000-0003-0118-0341
Univ Cambridge, MRC Biostat Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.ORCID iD: 0000-0003-2815-1217
2018 (English)In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 57, no 12, p. 2145-2148Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate whether overall obesity (as measured by BMI) and abdominal obesity (as measured by waist-to-hip ratio adjusted for BMI) are associated with gout risk and serum urate concentrations using Mendelian randomization.

Methods: Single nucleotide polymorphisms associated with BMI (n = 97) and waist-to-hip ratio adjusted for BMI (n = 49) were analysed for association with gout risk in 2115 gout cases and 67 259 controls, and with serum urate concentrations in 110 347 individuals from the Global Urate Genetics Consortium.

Results: Genetically higher BMI, but not waist-to-hip ratio adjusted for BMI, was positively associated with risk of gout and serum urate concentrations. Each standard deviation (about 4.6 kg/m(2)) increase in genetically predicted BMI was associated with an odds ratio of gout of 2.24 (95% CI 1.70, 2.95; P = 8.4 x 10(-9)) and with a 0.30 mg/dl (95% CI 0.25, 0.35; P = 1.6 x 10(-36)) increase in serum urate concentrations.

Conclusion: These findings provide support that overall obesity may be a risk factor for gout and is associated with higher serum urate concentrations.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2018. Vol. 57, no 12, p. 2145-2148
Keywords [en]
adiposity, body mass index, gout, Mendelian randomization, obesity, urate
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-376898DOI: 10.1093/rheumatology/key229ISI: 000456557500015PubMedID: 30085130OAI: oai:DiVA.org:uu-376898DiVA, id: diva2:1287805
Available from: 2019-02-12 Created: 2019-02-12 Last updated: 2019-11-19Bibliographically approved

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Michaëlsson, Karl

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