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Heparan sulfate proteoglycan - A common receptor for diverse cytokines
Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-4255-3581
2019 (English)In: Cellular Signalling, ISSN 0898-6568, E-ISSN 1873-3913, Vol. 54, p. 115-121Article in journal (Refereed) Published
Abstract [en]

Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed ubiquitously on the cell surface and in the extracellular matrix where they interact with a wide range of ligands to regulate many aspects of cellular function. The capacity of the side glycosaminoglycan chain heparan sulfate (HS) being able to interact with diverse protein ligands relies on its complex structure that is generated by a controlled biosynthesis process, involving the actions of glycosyl-transferases, sulfotransferases and the glucuronyl C5-epimerase. It is believed that activities of the modification enzymes control the HS structures that are designed to serve the biological functions in a given cell or biological status. In this review, we briefly discuss recent understandings on the roles of HSPG in cytokine stimulated cellular signaling, focusing on FGF, TGF-beta, Wnt, Hh, HGF and VEGF.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 54, p. 115-121
Keywords [en]
Heparan sulfate proteoglycan, Cytokines, Cellular signaling, Heparin
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-376715DOI: 10.1016/j.cellsig.2018.11.022ISI: 000456752900012PubMedID: 30500378OAI: oai:DiVA.org:uu-376715DiVA, id: diva2:1288024
Funder
Swedish Research Council, 2015-02595Swedish Cancer Society, CAN2015/496Available from: 2019-02-12 Created: 2019-02-12 Last updated: 2019-02-12Bibliographically approved

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Li, Jin-Ping

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