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Titanium release in peri-implantitis
Umea Univ, Dept Odontol, Prosthet Dent, Fac Med, Umea, Sweden.ORCID iD: 0000-0001-5992-8135
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.ORCID iD: 0000-0003-4764-1246
Umea Univ, Dept Odontol, Mol Periodontol, Fac Med, Umea, Sweden.ORCID iD: 0000-0002-8069-8263
Umea Univ, Dept Odontol, Prosthet Dent, Fac Med, Umea, Sweden.
2019 (English)In: Journal of Oral Rehabilitation, ISSN 0305-182X, E-ISSN 1365-2842, Vol. 46, no 2, p. 179-188Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to investigate the titanium (Ti) content of biopsies from patients with severe peri-implantitis or controls without Ti exposure.

Background: Peri-implantitis is considered to be an infectious disease, but recent studies have shown that Ti can aggravate inflammation in combination with bacterial products. The Ti content of peri-implantitis and periodontitis (controls) tissue is unknown.

Methods: Thirteen patients referred for peri-implantitis and eleven for periodontitis treatment were included in the study. Disease severity was obtained from dental records. Biopsies were taken from both groups and chemically analysed with inductively coupled plasma mass spectrometry for Ti content. Additionally, two patients with peri-implantitis and two with periodontitis were recruited and their biopsies were analysed microscopically with light microscopy, transmission electron microscopy and scanning electron microscopy with element analysis to investigate the presence of particulate Ti.

Results: All patients lost one or more implants despite undergoing peri-implant or treatment. Peri-implantitis tissue contained significantly higher concentrations of Ti than control samples with a mean +/- SD of 98.7 +/- 85.6 and 1.2 +/- 0.9 mu g/g, respectively. Particulate metal was identified in peri-implantitis and control biopsies, but element analyses could confirm only the presence of Ti in peri-implantitis tissue.

Conclusion: We showed that high contents of particulate and submicron Ti were present in peri-implantitis tissue. These high Ti contents in peri-implant mucosa can potentially aggravate inflammation, which might reduce the prognosis of treatment interventions.

Place, publisher, year, edition, pages
2019. Vol. 46, no 2, p. 179-188
Keywords [en]
energy dispersive X-ray spectroscopy, inductively coupled plasma mass spectrometry, light microscopy, peri-implantitis, scanning electron microscopy, titanium
National Category
Dentistry
Identifiers
URN: urn:nbn:se:uu:diva-375808DOI: 10.1111/joor.12735ISI: 000455483300010PubMedID: 30325523OAI: oai:DiVA.org:uu-375808DiVA, id: diva2:1288216
Funder
Västerbotten County Council, VLL 1147-2014Available from: 2019-02-12 Created: 2019-02-12 Last updated: 2019-02-12Bibliographically approved

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