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Advances in mass spectrometry based single-cell metabolomics
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.ORCID iD: 0000-0003-0575-0858
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.ORCID iD: 0000-0001-9040-3230
2019 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 144, no 3, p. 782-793Article, review/survey (Refereed) Published
Abstract [en]

Metabolomics has grown into a prominent field contributing to the molecular understanding of complex biological processes in both health and disease. Furthermore, single-cells are known to display metabolic differences between seemingly homogeneous populations of cells. Single-cell metabolomics attempts to analyze many cellular metabolites from single cells to understand phenotypic heterogeneity, which is a significant challenge due to the low analyte abundances and limited sample volumes. Label-free metabolite detection can be achieved with mass spectrometry, which is capable of simultaneously analyzing hundreds of metabolites. Herein, we review the recent advances in mass spectrometry based single-cell metabolomics, highlighting the current state-of-the-art within the last three years, and identify the challenges to move the field forward.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2019. Vol. 144, no 3, p. 782-793
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-377492DOI: 10.1039/c8an01581cISI: 000457394400004PubMedID: 30426983OAI: oai:DiVA.org:uu-377492DiVA, id: diva2:1290458
Funder
Swedish Foundation for Strategic Research Swedish Research CouncilAvailable from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-02-20Bibliographically approved

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Duncan, Kyle D.Lanekoff, Ingela

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