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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.ORCID iD: 0000-0001-8698-2866
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.ORCID iD: 0000-0001-8698-2866
Number of Authors: 4282019 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 51, no 2, p. 245-257Article in journal (Refereed) Published
Abstract [en]

Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (vertical bar(r) over cap (g)vertical bar similar to 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 51, no 2, p. 245-257
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-377211DOI: 10.1038/s41588-018-0309-3ISI: 000457314300011PubMedID: 30643258OAI: oai:DiVA.org:uu-377211DiVA, id: diva2:1291612
Funder
Swedish Research Council, 421-2013-1061EU, European Research Council, 647648 EdGe
Note

For complete list of authors see http://dx.doi.org/10.1038/s41588-018-0309-3

Available from: 2019-02-25 Created: 2019-02-25 Last updated: 2019-02-25Bibliographically approved

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Oskarsson, SvenLindgren, Karl-Oskar

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