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miR-31 regulates energy metabolism and is suppressed in Tcells from patients with Sjögren's syndrome
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Karolinska Univ Hosp, Ctr Mol Med, Unit Rheumatol,Dept Med, CMM L8 04, SE-17176 Stockholm, Sweden.
Karolinska Inst, Karolinska Univ Hosp, Ctr Mol Med, Unit Rheumatol,Dept Med, CMM L8 04, SE-17176 Stockholm, Sweden.
Karolinska Inst, Karolinska Univ Hosp, Ctr Mol Med, Unit Rheumatol,Dept Med, CMM L8 04, SE-17176 Stockholm, Sweden;Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, 1275 York Ave, New York, NY 10021 USA;Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
Karolinska Inst, Karolinska Univ Hosp, Dept Mol Med & Surg, Rolf Luft Res Ctr Diabet & Endocrinol, Stockholm, Sweden.
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2019 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 49, no 2, p. 313-322Article in journal (Refereed) Published
Abstract [en]

Systemic autoimmune diseases are characterized by the overexpression of type I IFN stimulated genes, and accumulating evidence indicate a role for type I IFNs in these diseases. However, the underlying mechanisms for this are still poorly understood. To explore the role of type I IFN regulated miRNAs in systemic autoimmune disease, we characterized cellular expression of miRNAs during both acute and chronic type I IFN responses. We identified a Tcell-specific reduction of miR-31-5p levels, both after intramuscular injection of IFN and in patients with Sjogren's syndrome (SjS). To interrogate the role of miR-31-51p in Tcells we transfected human CD4(+) Tcells with a miR-31-5p inhibitor and performed metabolic measurements. This identified an increase in basal levels of glucose metabolism after inhibition of miR-31-5p. Furthermore, treatment with IFN- also increased the basal levels of human CD4(+) T-cell metabolism. In all, our results suggest that reduced levels of miR-31-5p in Tcells of SjS patients support autoimmune T-cell responses during chronic type I IFN exposure.

Place, publisher, year, edition, pages
2019. Vol. 49, no 2, p. 313-322
Keywords [en]
Autoimmunity, Interferons, Immune regulation, Metabolism, Rheumatology
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-378189DOI: 10.1002/eji.201747416ISI: 000458699200011PubMedID: 30307034OAI: oai:DiVA.org:uu-378189DiVA, id: diva2:1293226
Funder
Swedish Research Council, 521-2012-1827The Karolinska Institutet's Research FoundationNovo NordiskAvailable from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-03-04Bibliographically approved

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Johansson, Alina

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