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Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths
Rovira & Virgili Univ, Dept Elect Elect & Automat Engn, Tarragona, Spain.ORCID iD: 0000-0003-2553-946X
Univ Tunis El Manar, Lab Epidemiol & Vet Microbiol, Inst Pasteur Tunis, Tunis, Tunisia.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics. Mol Fingerprint AB Sweden, Uppsala, Sweden.ORCID iD: 0000-0003-0296-5247
Univ Ctr Maritime & Trop Med, Gdynia Redlowo, Poland.
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2019 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 219, no 1, p. 101-109Article in journal (Refereed) Published
Abstract [en]

Background: Human echinococcosis is a neglected infectious disease affecting more than 1 million people globally. Its diagnosis is expensive and difficult because of lack of adequate resources in low-resource locations, where most cases occur.

Methods: A group of volunteers diagnosed with the 2 main types of echinococcosis and corresponding control groups were recruited from hospitals in Tunisia (32 patients with cystic echinococcosis and 43 controls) and Poland (16 patients with alveolar echinococcosis and 8 controls). Breath samples were collected from all patients and analyzed by gas chromatography coupled to mass spectrometry, and a specifically developed electronic nose system.

Results: The chemical analysis revealed statistically different concentrations of 2 compounds in the breath of patients with cystic echinococcosis compared to controls, and statistically different concentrations of 7 compounds in the breath of patients with alveolar echinococcosis compared to controls. The discrimination accuracy achieved by the electronic nose system was 100% for cystic echinococcosis and 92.9% for alveolar echinococcosis, while the discrimination accuracy between these 2 patient groups was 92.1%.

Conclusion: Here we advocate a noninvasive, fast, easy-to-operate and nonexpensive diagnostic tool for the diagnosis of human echinococcosis disease through exhaled breath analysis, suitable for early diagnosis and population screening.

Place, publisher, year, edition, pages
2019. Vol. 219, no 1, p. 101-109
Keywords [en]
echinococcosis, diagnosis, breath analysis, biomarkers, chemical sensors
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-378686DOI: 10.1093/infdis/jiy449ISI: 000458610200014PubMedID: 30016445OAI: oai:DiVA.org:uu-378686DiVA, id: diva2:1295680
Funder
EU, Horizon 2020, 645758Available from: 2019-03-12 Created: 2019-03-12 Last updated: 2019-03-12Bibliographically approved

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Österlund, LarsCindemir, UmutIonescu, Radu

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