uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England;Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Parkville, Vic, Australia;Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia.
Show others and affiliations
2019 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 51, no 3, p. 481-493Article in journal (Refereed) Published
Abstract [en]

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.

Place, publisher, year, edition, pages
2019. Vol. 51, no 3, p. 481-493
National Category
Medical Genetics Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-379345DOI: 10.1038/s41588-018-0321-7ISI: 000459947200016PubMedID: 30804560OAI: oai:DiVA.org:uu-379345DiVA, id: diva2:1296415
Funder
Wellcome trust, WT202849/Z/16/ZAvailable from: 2019-03-15 Created: 2019-03-15 Last updated: 2019-03-15Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Enroth, StefanLind, LarsGyllensten, Ulf B.

Search in DiVA

By author/editor
Hobbs, Brian D.Enroth, StefanLind, LarsGyllensten, Ulf B.Wain, Louise, V
By organisation
Medicinsk genetik och genomikScience for Life Laboratory, SciLifeLabClinical Epidemiology
In the same journal
Nature Genetics
Medical GeneticsRespiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 80 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf