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Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany.ORCID iD: 0000-0003-3974-1482
Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England; Imperial Coll London, Natl Heart & Lung Inst, London, England.
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
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2019 (English)In: Respiratory Research, ISSN 1465-9921, E-ISSN 1465-993X, Vol. 20, article id 33Article in journal (Refereed) Published
Abstract [en]

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Associations of SHS exposure with respiratory health (asthma symptom score, asthma, chronic bronchitis, COPD) were analysed using generalised linear mixed-effects models adjusted for confounding factors (including sex, age, smoking status, socioeconomic status and allergic sensitisation). Linear mixed-effects models with additional adjustment for height were used to assess the relationships between SHS exposure and lung function levels and decline.

Results: Reported exposure to SHS decreased in all 26 study centres over time. The prevalence of SHS exposure was 38.7% at baseline (1990–1994) and 7.1% after the 20-year follow-up (2008–2011). On average 2.4% of the study participants were not exposed at the first, but were exposed at the third examination. An increase in SHS exposure over time was associated with doctor-diagnosed asthma (odds ratio (OR): 2.7; 95% confidence interval (95%-CI): 1.2–5.9), chronic bronchitis (OR: 4.8; 95%-CI: 1.6–15.0), asthma symptom score (count ratio (CR): 1.9; 95%-CI: 1.2–2.9) and dyspnoea (OR: 2.7; 95%-CI: 1.1–6.7) compared to never exposed to SHS. Associations between increase in SHS exposure and incidence of COPD (OR: 2.0; 95%-CI: 0.6–6.0) or lung function (β: − 49 ml; 95%-CI: -132, 35 for FEV1 and β: − 62 ml; 95%-CI: -165, 40 for FVC) were not apparent.

Conclusion: Exposure to second-hand smoke may lead to respiratory symptoms, but this is not accompanied by lung function changes.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 20, article id 33
Keywords [en]
Adults, Smoking, Lung function, Asthma, Respiratory symptoms, Bronchitis, ECRHS
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-378997DOI: 10.1186/s12931-019-0996-zISI: 000459188400002PubMedID: 30764884OAI: oai:DiVA.org:uu-378997DiVA, id: diva2:1297244
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareForte, Swedish Research Council for Health, Working Life and WelfareForte, Swedish Research Council for Health, Working Life and WelfareForte, Swedish Research Council for Health, Working Life and WelfareForte, Swedish Research Council for Health, Working Life and WelfareThe Research Council of NorwayWellcome trust, WT 084703MASwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationGerman Research Foundation (DFG), FR1526/1-1Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved

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Janson, Christer

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