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Combined Testing of p16 Tumour-suppressor Protein and Human Papillomavirus in Patients With Oral Leukoplakia and Oral Squamous Cell Carcinoma
Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg, Sweden.
NAL Hosp, Clin Orofacial Med & Maxillofacial Surg, Trollhattan, Sweden.
NAL Hosp, Clin Orofacial Med & Maxillofacial Surg, Trollhattan, Sweden.
Sahlgrenska Univ Hosp East, Clin Orofacial Med, Gothenburg, Sweden.
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2019 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 39, no 3, p. 1293-1300Article in journal (Refereed) Published
Abstract [en]

Background: Oral leukoplakia (OL) is a potentially malignant oral mucosal disorder. A casual association between OL, oral squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection has been suggested, but no conclusive evidence has been presented. p16, a tumour-suppressor protein, is used as a surrogate marker for HPV infection. The aim of this study was to investigate how overexpression of p16 correlates with HPV infection in OL and in OSCC.

Patients and Methods: Seventy-four patients with OL and 13 with OSCC with p16 overexpressed, were analyzed by immunohistochemistry visualizing p16 and a real-time polymerase chain reaction (PCR) assay targeting HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 52, 56, 58 and 59.

Results: Overexpression of p16 was observed in 18% of patients with OL. None of the HPV subtypes were detected by PCR analysis in patients with OL. In the p16-positive OSCC specimens, 38% were also HPV16-positive.

Conclusion: Overexpression of p16 was not found to be a reliable biomarker for HPV infection in patients with OL and OSCC.

Place, publisher, year, edition, pages
INT INST ANTICANCER RESEARCH , 2019. Vol. 39, no 3, p. 1293-1300
Keywords [en]
Potentially malignant oral disorders, oral cancer, tumour suppressor protein, virus infection, biomarker
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-379900DOI: 10.21873/anticanres.13241ISI: 000460403800024PubMedID: 30842161OAI: oai:DiVA.org:uu-379900DiVA, id: diva2:1298143
Available from: 2019-03-22 Created: 2019-03-22 Last updated: 2019-03-22Bibliographically approved

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Blomstrand, LenaHirsch, Jan-Michael

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