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Basic and practical concepts of radiopharmaceutical purification methods
Mazandaran Univ Med Sci, Dept Radiopharm, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran;Mazandaran Univ Med Sci, Student Res Comm, Fac Pharm, Sari, Iran.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.ORCID iD: 0000-0002-6122-1734
Mazandaran Univ Med Sci, Dept Radiopharm, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran.ORCID iD: 0000-0001-8055-8036
2019 (English)In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 24, no 1, p. 315-324Article, review/survey (Refereed) Published
Abstract [en]

The presence of radiochemical impurities in a radiopharmaceutical contributes to an unnecessary radiation burden for the patients or to an undesirable high radioactivity background, which reduces the imaging contrast or therapeutic efficacy. Therefore, if the radiolabeling process results in unsatisfactory radiochemical purity, a purification step is unavoidable. A successful purification process requires a profound knowledge about the radiopharmaceuticals of interest ranging from structural features to susceptibility to different conditions. Most radiopharmaceutical purification methods are based on solid phase extraction (SPE), high-performance liquid chromatography (HPLC), size exclusion chromatography (SEC), ion-exchange chromatography (IEC), and liquid-liquid extraction (LLE). Here, we discuss the basic and applied concepts of these purifications methods as well as their advantages and limitations.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 24, no 1, p. 315-324
National Category
Pharmaceutical Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-379953DOI: 10.1016/j.drudis.2018.09.018ISI: 000460194900036PubMedID: 30278224OAI: oai:DiVA.org:uu-379953DiVA, id: diva2:1298845
Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-03-25Bibliographically approved

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