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Cardenolides: Insights from chemical structure and pharmacological utility
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur, Malaysia; Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi, Pakistan; Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt.
Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Natl Org Drug Control & Res NODCAR, Cairo, Egypt; KTH, Royal Inst Technol, Dept Chem, Stockholm, Sweden.
Cairo Univ, Coll Pharm, Dept Pharmacognosy, Kasr el Aini St, Cairo, Egypt; Amer Univ Cairo, Sch Sci & Engn, Dept Chem, New Cairo, Egypt.
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2019 (English)In: Pharmacological Research, ISSN 1043-6618, E-ISSN 1096-1186, Vol. 141, p. 123-175Article, review/survey (Refereed) Published
Abstract [en]

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+/K+ -ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer. In this review, we highlight some of the structural features of this class of natural products that are crucial for their efficacy, some methods of isolating these compounds from natural resources, and the structural elucidation tools that have been used. We also describe their physicochemical properties and several modern biotechnological approaches for preparing CGs that do not require plant sources.

Place, publisher, year, edition, pages
2019. Vol. 141, p. 123-175
Keywords [en]
Cardiac glycosides, Chemical property space, Isolation, Heart failure
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-380669DOI: 10.1016/j.phrs.2018.12.015ISI: 000460997000011PubMedID: 30579976OAI: oai:DiVA.org:uu-380669DiVA, id: diva2:1300980
Funder
Swedish Research Council, 2016-05908Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01Bibliographically approved

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El-Seedi, Hesham R.Alajlani, Muaaz M.

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