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SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
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2011 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 41, no 1, p. 134-40Article in journal (Refereed) Published
Abstract [en]

Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.

Place, publisher, year, edition, pages
2011. Vol. 41, no 1, p. 134-40
National Category
Medical Genetics
Research subject
Molecular Genetics
Identifiers
URN: urn:nbn:se:uu:diva-373465DOI: 10.1007/s10519-010-9431-4PubMedID: 21203819OAI: oai:DiVA.org:uu-373465DiVA, id: diva2:1301215
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01

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