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Advantages of microfluidic systems for studying cell-biomaterial interactions: focus on bone regeneration applications
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. (EMBLA/MST)ORCID iD: 0000-0001-7462-4236
Universitat Internacional de Catalunya (Spain).
Universidad Nacional del Sur (Argentina).
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Uppsala University, Science for Life Laboratory, SciLifeLab. (EMBLA/MST)ORCID iD: 0000-0003-4475-6478
2019 (English)In: Biomedical Physics & Engineering Express, ISSN 2057-1976, Vol. 5, no 3, article id 032001Article, review/survey (Refereed) Published
Abstract [en]

The poor correlation between in vitro and in vivo studies emphasises the lack of a reliable methodology for testing the biological properties of biomaterials in the bone tissue regeneration field. Moreover, the success of clinical trials is not guaranteed even with promising results in vivo. Therefore, there is a need for a more physiologically relevant in vitro model to test the biological properties of biomaterials. Microfluidics, which is a field concerning the manipulation and control of liquids at the submillimetre scale, can use channel geometry, cell confinement and fluid flow to recreate a physiological-like environment. This technology has already proven to be a powerful tool in studying the biological response of cells in defined environments, since chemical and mechanical inputs as well as cross-talk between cells can be finely controlled. Moving a step further in complexity, biomaterials can be integrated into microfluidic systems to evaluate biomaterial-cell interactions. The biomaterial- microfluidics combination has the potential to produce more physiologically relevant models to better screen the biological interactions established between biomaterials and cells. This review is divided into two main sections. First, several possible cell-based assays for bone regeneration studies in microfluidic systems are discussed. Second, and the ultimate goal of the review, is to discuss how the gap between in vitro and in vivo studies can be shortened by bridging the biomaterials and microfluidics fields.

Place, publisher, year, edition, pages
2019. Vol. 5, no 3, article id 032001
Keywords [en]
bone regeneration, biomaterials, in vitro, microfluidics, microsystems, cell culture
National Category
Materials Engineering
Identifiers
URN: urn:nbn:se:uu:diva-381400DOI: 10.1088/2057-1976/ab1033ISI: 000463561300001OAI: oai:DiVA.org:uu-381400DiVA, id: diva2:1303286
Funder
Swedish Research Council Formas, 2016-00781Swedish Research Council, 2017-05051Göran Gustafsson Foundation for Research in Natural Sciences and Medicine, 1841The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), IB2017-7362Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-04-25Bibliographically approved

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The full text will be freely available from 2020-04-06 08:51
Available from 2020-04-06 08:51

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Mestres, GemmaBarbe, Laurent

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