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Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.ORCID iD: 0000-0002-4935-7532
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.ORCID iD: 0000-0002-2491-2042
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.
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2019 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 103, p. 296-305Article in journal (Refereed) Published
Abstract [en]

Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35-39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35-39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women.

Place, publisher, year, edition, pages
2019. Vol. 103, p. 296-305
Keywords [en]
Cortisol, Gene, Hormones, Hypothalamic-pituitary-adrenal axis, Perinatal depression, Postpartum depression, Single nucleotide polymorphism, Stress
National Category
Endocrinology and Diabetes Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-381817DOI: 10.1016/j.psyneuen.2019.02.002ISI: 000465367000038PubMedID: 30776573OAI: oai:DiVA.org:uu-381817DiVA, id: diva2:1304848
Funder
Swedish Research Council, 521-2013-2339Marianne and Marcus Wallenberg Foundation, MMW2011.0115The Swedish Medical Association, SLS-250581Forte, Swedish Research Council for Health, Working Life and Welfare, 2011-0627Swedish Society of Medicine, SLS-331991Swedish Research Council, 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398
Note

De 2 första författarna delar förstaförfattarskapet.

Available from: 2019-04-15 Created: 2019-04-15 Last updated: 2019-06-18Bibliographically approved

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Skalkidou, AlkistisSundström Poromaa, IngerIliadis, Stavros I.Hellgren, CharlotteFreyhult, EvaComasco, Erika

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Skalkidou, AlkistisSundström Poromaa, IngerIliadis, Stavros I.Hellgren, CharlotteFreyhult, EvaComasco, Erika
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