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Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.ORCID iD: 0000-0002-4935-7532
Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA.
Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France;Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.
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2019 (English)In: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 59, p. 158-165Article in journal (Refereed) Published
Abstract [en]

Background:

Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.

Aim:

To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.

Material/methods:

We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants < 1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.

Results:

Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers >= 40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.

Conclusions:

An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.

Place, publisher, year, edition, pages
2019. Vol. 59, p. 158-165
Keywords [en]
Infant acute myeloid leukemia, Childhood cancer, Epidemiology, Maternal age, Paternal age, Risk factors
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-382258DOI: 10.1016/j.canep.2019.01.022ISI: 000462487700022PubMedID: 30776582OAI: oai:DiVA.org:uu-382258DiVA, id: diva2:1306416
Available from: 2019-04-23 Created: 2019-04-23 Last updated: 2019-04-23Bibliographically approved

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Skalkidou, Alkistis

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