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Furry Animal Allergen Component Sensitization and Clinical Outcomes in Adult Asthma and Rhinitis
Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Inst Med, Gothenburg, Sweden.
Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden;Showa Univ, Dept Med, Div Allergol & Resp Med, Sch Med, Tokyo, Japan.
Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
ThermoFisher Sci, ImmunoDiagnost, Uppsala, Sweden.
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2019 (English)In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 7, no 4, p. 1230-1238Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Sensitization to allergen components has been linked to asthma in children, but studies in adults are lacking.

OBJECTIVE: To study the relation of sensitization to furry animal allergen components to risk of asthma, rhinitis, and markers of asthma severity in adults.

METHODS: From the West Sweden Asthma Study, a random population-representative sample of adults aged 16 to 75 years, 2006 participants were clinically examined; 1872 were analyzed for serum IgE level to a mix of aeroallergens. Those with an IgE level of more than 0.35 kU(A)/L to cat, dog, or horse allergen components were analyzed for specific cat (Felis domesticus [Fel d 1, Fel d 2, and Fel d 4]), dog (Canis familiaris [Can f 1, Can f 2, Can f 3, and Can f 5]), and horse (Equus caballus [Equ c 1]) allergen components. We defined monosensitization, double sensitization, and polysensitization (>2 components) patterns and applied cluster analysis to derive distinct sensitization clusters.

RESULTS: Sensitization to each allergen component, lipocalins, each sensitization pattern, and each sensitization cluster (nonsensitized, Fel d 1-driven sensitized, and multisensitized clusters) was associated with substantial increased risk of asthma, rhinitis, concomitant asthma and rhinitis, and Asthma Control Test-controlled asthma. Fel d 1, Can f 1, Can f 2, Can f 3, polysensitization, and multisensitized cluster were further associated with increased fractional exhaled nitric oxide and eosinophil levels, but with lower PD20 methacoline (provocative dose of methacholine causing a 20% drop in FEV1) values. There was no association with asthma exacerbations, FEV1 predicted values, emergency visits or regular oral steroid use, and neutrophil levels.

CONCLUSIONS: Sensitization to furry animal allergen components is an important predictor of asthma, rhinitis, and markers of asthma severity with increased blood eosinophils, fractional exhaled nitric oxide, and airway hyperreactivity.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2019. Vol. 7, no 4, p. 1230-1238
Keywords [en]
Asthma, Adults, Component-resolved diagnostics, Cat components, Dog components, Horse components, Cluster analysis, Furry animal, Severe asthma, Western Sweden
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-382392DOI: 10.1016/j.jaip.2018.12.018ISI: 000463732500019PubMedID: 30594587OAI: oai:DiVA.org:uu-382392DiVA, id: diva2:1307171
Funder
Swedish Research CouncilSwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationAvailable from: 2019-04-26 Created: 2019-04-26 Last updated: 2019-04-26Bibliographically approved

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