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Characterization of sensitization to furry animal allergen components in an adult population
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden; Showa Univ, Sch Med, Dept Med, Div Allergol & Resp Med, Tokyo, Japan.
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden; Univ Gothenburg, Inst Med, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.ORCID iD: 0000-0002-2876-6089
Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden.
Thermo Fisher Sci, ImmunoDiagnost, Uppsala, Sweden.
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2019 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 49, no 4, p. 495-505Article in journal (Refereed) Published
Abstract [en]

Background: There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.

Objective: To characterize sensitization patterns to furry animal allergen components in Swedish adults.

Methods: Based on the West Sweden Asthma Study, a random population (n = 1103) and an asthma sample (n = 769) were tested for allergen sensitization using Phadiatop®. Those with IgE ≥ 0.35 kUA/L were tested for cat (Fel d 1, 2, and 4), dog (Can f 1, 2, 3, and 5), and horse (Equ c 1) allergen component sensitization. We defined allergen component poly‐sensitization patterns, identified data‐driven sensitization clusters, described component sensitization overlaps, and assessed determinants of sensitization patterns.

Results: The prevalence of allergen component sensitization ranged from 0.8% for Fel d 2 and Can f 3 to 8.9% for Fel d 1. The most common dog component was Can f 5 (3.6%); 2.1% were sensitized to Equ c 1. Those sensitized to Fel d 2 and Fel d 4 were commonly sensitized to Fel d 1. The most common dog component overlap was between Can f 1/Can f 2 and Can f 5. Mono‐sensitization was 5.6%, double sensitization 1.5% and poly‐sensitization 2.1%. Sensitization was always higher in the asthma than in the random sample. Three sensitization clusters were derived, namely non‐sensitized (90% in random vs 66% in asthma sample); Fel d 1‐driven sensitized (7% vs 19%); and multi‐sensitized (3% vs 15%). Key determinants of sensitization were gender, age, raised on a farm, family history of allergy or asthma, smoking, and occupational exposure to dust or fumes.

Conclusions & Clinical Relevance: Fel d 1 and Can f 5 are the most common cat and dog components sensitization in this adult Swedish population. Mono‐sensitization is more common than poly‐sensitization. This detailed characterization highlights the current distribution of furry animal allergen components in Swedish adults, and their impact on clinical outcomes of asthma will be further explored.

Place, publisher, year, edition, pages
2019. Vol. 49, no 4, p. 495-505
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-382652DOI: 10.1111/cea.13355ISI: 000463761700012PubMedID: 30697845OAI: oai:DiVA.org:uu-382652DiVA, id: diva2:1307787
Funder
Swedish Research CouncilSwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationRegion Västra GötalandAvailable from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved

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