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Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes
Novo Nordisk Res Ctr Seattle Inc, Seattle, WA 98109 USA.
Novo Nordisk Res Ctr Seattle Inc, Seattle, WA 98109 USA.
Novo Nordisk Res Ctr Seattle Inc, Seattle, WA 98109 USA.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
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2019 (English)In: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 29, no 4, p. 795-802Article, review/survey (Refereed) Published
Abstract [en]

Recent articles have highlighted the lack of reproducibility of data from scientific publications. Here we would argue that a better way to describe and also tackle this matter is to use the term "lack of robustness," since it points toward potential solutions. Presenting several case reports, we highlight examples with common underlying issues from Novo Nordisk's experience: animal model variability, reagent quality, and inter-lao variability. We discuss means to prevent these issues and argue for increased collaborative work and transparent manuscript revision procedures. Collectively, we believe these measures will help promote a more rapid and efficient self-corrective process in diabetes drug target research.

Place, publisher, year, edition, pages
CELL PRESS , 2019. Vol. 29, no 4, p. 795-802
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Cell Biology Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-382768DOI: 10.1016/j.cmet.2019.02.004ISI: 000463015800005PubMedID: 30879984OAI: oai:DiVA.org:uu-382768DiVA, id: diva2:1313341
Available from: 2019-05-03 Created: 2019-05-03 Last updated: 2019-05-03Bibliographically approved

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Christoffersson, Gustaf

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